about the pi
Dr. Dong Wang obtained his B.S. at Peking University and Ph.D. with Dr. Stephen Lippard at MIT. His role in Lippard group was to investigate the effect of nucleosome structure and epigenetic status change on DNA repair of platinum DNA damage. Dr. Wang then joined Dr. Roger Kornberg’s group at Stanford University as a postdoc fellow. His postdoc research focused on understanding the molecular mechanism of Pol II transcription elongation and fidelity.
About the Wang group
Our research focuses on understanding the mechanisms of cellular responses to DNA damage, particularly the functional interplay between transcription and epigenetic DNA modifications and lesions. We take a multidisciplinary approach, combining structural biology, chemical biology, computational biology, biochemical, and genetic methods, to study key protein complexes involved in these processing pathways. The results will have implications for DNA damage recognition and DNA repair. Moreover, understanding how cell process these DNA lesions will help us to decipher the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.